I know that many of you have been saying Chrono Crusade. I've read the manga, and that came close to making me cry. However, by the time I read it, I knew the basics on how the anime ended, and the manga storyline is AMAZINGLY emotional. I have seen some of the anime since I finished the manga (not the ending, though) and truthfully, some of the changes sort of pissed me off, such as Rosette experiencing stigmata. (I would like to see it in full, though, but only if it's in the English dub; I know that they set the script to match the speech-styles of that time period, which makes it great by default).